Sacubitril / Valsartan 24 mg / 26 mg film-coated tablets
What Sacubitril / Valsartan is and what it is used for:
This medicine contains an angiotensin receptor neprilysin inhibitor. It delivers two active substances, sacubitril and valsartan.
It is used to treat a type of long-term heart failure in adults.
This type of heart failure occurs when the heart is weak and cannot pump enough blood to the lungs and the rest of the body.
The most common symptoms of heart failure are shortness of breath, fatigue, tiredness, and ankle swelling.
If you have any questions about how Sacubitril / Valsartan works or why this medicine has been prescribed for you, ask your doctor.
Do not take Sacubitril / Valsartan:
- If you are allergic to sacubitril, valsartan, or any of the other ingredients of this medicine.
- If you are taking another type of medicine called an ACE inhibitor (e.g., enalapril, lisinopril, or ramipril). ACE inhibitors are used to treat high blood pressure or heart failure. If you have been taking an ACE inhibitor, wait 36 hours after taking the last dose before you start taking this medicine.
- If you or a family member has ever had a reaction called angioedema (swelling of the face, lips, tongue, and/or throat, difficulties in breathing) when taking an ACE inhibitor or an angiotensin receptor blocker (ARB) (such as valsartan, telmisartan, or irbesartan).
- If you have diabetes or impaired kidney function and you are being treated with a blood pressure-lowering medicine containing aliskiren.
- If you have severe liver disease.
- If you are more than 3 months pregnant (it is also better to avoid this medicine in early pregnancy).
Warnings and Precautions:
Talk to your doctor or pharmacist before taking Sacubitril / Valsartan:
- If you are being treated with an angiotensin receptor blocker (ARB) or aliskiren.
- If you have ever experienced angioedema.
- If you have low blood pressure or are taking any other medicines that reduce blood pressure (e.g., a diuretic) or are suffering from vomiting or diarrhea, especially if you are aged 65 or older, or if you have kidney disease and low blood pressure.
- If you have severe kidney disease.
- If you are dehydrated.
- If your kidney artery has narrowed.
- If you have liver disease.
Other medicines and Sacubitril / Valsartan:
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. It is especially important to mention:
- ACE inhibitors (Do not take together; wait 36 hours between switching).
- Other medicines for heart failure or blood pressure, such as ARBs or aliskiren.
- Statins used to lower cholesterol (e.g., atorvastatin).
- Sildenafil, used for erectile dysfunction or pulmonary hypertension.
- Medicines that increase potassium levels in the blood (potassium supplements, salt substitutes containing potassium, potassium-sparing medicines, or heparin).
- Painkillers of the type called NSAIDs or selective Cox-2 inhibitors. Your doctor may want to check your kidney function when starting or adjusting treatment.
- Lithium, used for certain types of psychiatric illness.
- Furosemide, a diuretic used to increase urine production.
- Nitroglycerin, used to treat angina.
- Certain antibiotics (rifamycin group), cyclosporine, or antivirals such as ritonavir.
- Metformin, used to treat diabetes.
How to take Sacubitril / Valsartan:
You will usually start by taking 24 mg / 26 mg or 49 mg / 51 mg twice a day (one tablet in the morning and one in the evening). Your doctor will decide your exact starting dose. The dose will then be adjusted based on your response until the best dose for you is found. The usual recommended target dose is 97 mg / 103 mg twice a day.
Patients may experience low blood pressure, high blood potassium, or decreased kidney function. If this happens, your doctor may adjust your doses or temporarily stop treatment.
Swallow the tablets with a glass of water. You can take Sacubitril / Valsartan with or without food.
Possible side effects:
Stop taking Sacubitril / Valsartan and seek medical attention immediately if you notice any swelling of the face, lips, tongue, and/or throat, which may cause difficulties in breathing or swallowing (signs of angioedema).
How to store Sacubitril / Valsartan:
Keep this medicine out of the sight and reach of children. Do not use after the expiry date (EXP) stated on the carton and blister. The expiry date refers to the last day of that month. This medicine does not require any special temperature storage conditions. Store in the original package to protect from moisture.
Product Details:
Brand: Entresto
Concentration: 50 mg
Quantity: 28 Tablets
Product Type: Tablets
